EVERY DONATED ORGAN IS A GIFT
For patients with intestinal failure, an organ transplant offers the chance at a new life.
We’ve developed the first device designed specifically to keep the intestine safe and protected as it travels from donor to transplant recipient.
A RACE AGAINST TIME
Intestine remains the least commonly transplanted organ despite continuing need.
With advancements in immunosuppression and surgical techniques, the rate of successful intestinal transplants has increased, yet little has changed in the crucial intermediary step of keeping intestinal tissue viable.
The standard of care for transporting organs has not changed for 25 years – a cooler with ice. This transport method results in significant tissue damage and increases the risk of longer-term complications post-transplant.
The small intestines are especially vulnerable to damage and degrade quickly while in transit, constraining the potential recipient pool to those within a small geographic area. As a result, many adults and children die each year waiting for a new organ.
A NEW REALITY
Our co-founders at the Yale School of Medicine and School of Engineering and Applied Sciences, sought to develop a system that could improve the preservation of the graft during this period by perfusing both the intestinal lumen and vasculature.
The Revai Intestinal Preservation Unit (IPU) is a patent-pending dual perfusion system which preserves organ quality and keeps it healthy while it is transported from the organ donor to transplant recipient.
The IPU is designed to improve long-term outcomes, reduce overall healthcare costs and improve the quality of life for patients diagnosed with Intestinal Failure.
PUBLICATIONS & PRESENTATIONS
- Armando Salim Munoz-Abraham, Roger Patron-Lozano, Tariq Alfadda, Sami Judeeba, Abedalrazaq Alkukhun, Raja Narayan, David Mulligan, Raffaella Morotti, Joseph P. Zinter, John P. Geibel, Manuel I. Rodriguez-Davalos. Extracorporeal Hypothermic Perfusion Device for Human Intestine Preservation to Decrease Ischemic Injury During Graft Transportation. Journal of Gastrointestinal Surgery (2015).
- Armando Salim Munoz-Abraham, Roger Patron-Lozano, Sami Judeeba, Tariq Alfadda, Abedalrazaq Alkukhun, Joseph P. Zinter, John P. Geibel, Manuel I. Rodriguez-Davalos.
An Ex-vivo Hypothermic Perfusion Machine for Intestinal Graft Preservation. Abstract and video presentation at the 14th International Small Bowel Transplant Symposium. Buenos Aires, Argentina, 2015.
- Armando Salim Munoz-Abraham, Sami Judeeba, Abedalrazaq Alkukhun, Roger Patron-Lozano, Tariq Alfadda, Manuel I. Rodriguez-Davalos, John P. Geibel. Measurement of Intestinal Fluid Transport Using FITC-Inulin in Small Bowel Grafts of Rats. Abstract and oral presentation at the 14th International Small Bowel Transplant Symposium. Buenos Aires, Argentina, 2015.
- Raja R. Narayan, Natalie Pancer, Brian Loeb, Kristi E. Oki, Andrew Crouch, Spencer Backus, Yusuf Chauhan, Roger Patron-Lozano, Armando Salim Munoz-Abraham, Manuel I. Rodriguez-Davalos, John P. Geibel, Richard E. Fan, Joseph P. Zinter. A Novel Perfusion Device to Preserve Intestinal Tissue Ex-Vivo by Cold Peristaltic Perfusion. Abstract and oral presentation at the 36 Annual International Conference of the IEE Engineering in Medicine and Biology Society (EMBC'14). Chicago, IL 2014.
- Raja R. Narayan, Roger Patron-Lozano, Brian Loeb, Kristi E. Oki, Natalie Pancer, Andrew Crouch, Yusuf Chauhan, Spencer Backus, Richard E. Fan, Joseph P. Zinter, David C. Mulligan, Sukru H. Emre, John P. Geibel, Manuel I. Rodriguez-Davalos. When Tissue Is the Issue: A New Device for Extracorporeal Hypothermic Perfusion of Intestinal Lumen and Vasculature Decreases the Rate of Necrosis During Graft Transportation.
SSAT Abstracts 2014.
- Revai Startup Prolongs Viability of Intestines for Transplant - An organ transplant comes with a slew of complications, but perhaps the problem most overlooked is preserving the tissue once it is removed from the donor. READ MORE
- Student Entrepreneurs: Revai - A student startup is developing new technologies to help make intestinal transplants possible. READ MORE
- Organ Transporting Technology Developed At CEID, Presented at YEI Demo Day - Revai, a company made up of Yale students and faculty, has developed a better way to transport intestine. READ MORE
- Tackling Transplant Transportation - Through their work in the Medical Device Design Course (MENG 404), a team of Yale students won the first place prize of $10,000 in the BMEStart competition. READ MORE
- Organ Transport Team Wins $10,000 BMEStart Competition - Sponsored by the NCIIA, the competition recognizes the finest in undergraduate biomedical engineering innovation. READ MORE
- Safe transport - When it comes to organ transplants, the intestine has historically been off-limits. Unglamorous and, until recently, unsuccessful, intestinal transplants are complicated and difficult processes. READ MORE
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